![]() ![]() ![]() The S, E, M, and N genes encode structural proteins, whereas nonstructural proteins, such as 3-chymotrypsin-like protease, papain-like protease, and RNA-dependent RNA polymerase, are encoded by the ORF region. Gene fragments express structural and nonstructural proteins. An RNA-based metagenomic next-generation sequencing approach has been applied to characterize its entire genome, which is 29,881 bp in length (GenBank no. SARS-CoV-2 is a single-stranded RNA-enveloped virus. ![]() As the epidemic spreads, it is critical to find a specific therapeutic for COVID-19, and vaccines targeting various SARS-CoV-2 proteins are under development. Conversely, the other three, SARS-CoV, MERS-CoV, and SARS-CoV-2, are able to cause severe symptoms and even death, with fatality rates of 10%, 37%, and 5%, respectively.Īlthough a large number of studies and clinical trials are being launched on COVID-19 around the world, no evidence from randomized clinical trials has shown that any potential therapy improves outcomes in patients. It is the seventh known coronavirus to infect humans four of these coronaviruses (229E, NL63, OC43, and HKU1) only cause slight symptoms of the common cold. The COVID-19 was quickly discovered to be caused by a coronavirus later named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which belongs to the β coronavirus family. The epidemic of novel coronavirus disease 2019 (COVID-19) was caused by a new coronavirus occurred in December 2019, and now has spread worldwide and turned into a global pandemic. ![]()
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